In September 2005, Punk was assigned to Ohio Valley Wrestling (OVW), a WWE developmental territory.He made his debut on September 8, in a dark match, where he, Nigel Mc Guinness and Paul Burchill were defeated by Deuce Shade, Elijah Burke and Seth Skyfire.Though he had accepted the deal, Punk defeated Austin Aries to win the ROH World Championship on June 18 at Death Before Dishonor III.Immediately after the match, Punk proceeded to become a villain and started a storyline where he threatened to bring the ROH World Championship to WWE with him.On August 1, 2003, Punk wrestled for Japanese promotion Pro Wrestling ZERO-ONE on the final day of its Fire Festival at Korakuen Hall, teaming with C. Anderson, Josh Daniels, and Vansack Acid in an eight-man tag team match against Ikuto Hidaka, Jun Kasai, Naohiro Hoshikawa, and Tatsuhito Takaiwa; Punk's team was defeated.At the same time, Punk joined the wrestling promotion NWA: Total Nonstop Action, later known as Total Nonstop Action Wrestling (TNA), in which he was paired with Julio Dinero as members of Raven's TNA alliance The Gathering.On August 12, Punk lost the ROH World Championship to James Gibson in a four corner elimination match which also involved Samoa Joe and Christopher Daniels.In addition, most of the ROH roster contracted to TNA were pulled from the show because of a snowstorm that TNA officials thought might prevent performers from reaching a pay-per-view scheduled the next day.
When the promotion started taking off, doing shows out of a warehouse in Mokena, Illinois, Punk found out that his brother Mike had embezzled thousands of dollars from the small company, causing them to become estranged. During Punk's time in IWA Mid-South, he had high-profile feuds with Colt Cabana and Chris Hero while also rising to the top of the roster winning the IWA Mid-South Light Heavyweight Championship twice and the IWA Mid-South Heavyweight Championship on five separate occasions, beating stars like A. Styles, Cabana and even Eddie Guerrero in matches for the heavyweight championship.
Throughout his career, he won several championships including the WWE Championship twice, WWE's World Heavyweight Championship three times, and the ECW and ROH World Championships once each.
In WWE, he was also a one-time World Tag Team Champion (with Kofi Kingston), and one-time Intercontinental Champion, making him the 19th WWE Triple Crown Champion and the fastest man in WWE history to achieve this feat, doing so in 203 days.
He said the reason he and Dinero stopped appearing on TNA pay-per-views was that TNA officials believed that he and Dinero had not connected with the fans as villains, having turned against the popular Raven and instead formed a villainous tag team managed by James Mitchell.
Punk officially quit TNA in March 2004 during the Rob Feinstein controversy, after having a dispute with the TNA offices over his ability to compete in ROH following a TNA order that their contracted wrestlers were to no longer wrestle in ROH.
In addition, he was the 2011 WWE Superstar of the Year and the first two-time Money in the Bank winner.